29/09/2023 – B. Abou – Intracellular rheology of red blood cells
Séminaire IUSTI – 29 sept. 2023 – 11h salle 250
Intracellular rheology of red blood cells
Bérengère Abou – MSC, Paris
The characterisation of red blood cell stiffness and its heterogeneity in a blood sample is a key parameter for understanding red blood cell diseases. I will introduce a method to probe the intracellular rheology of red blood cells based on molecular rotors, which are fluorescent probes that are sensitive to viscosity. I will present the relevance of our approach in the context of erythrocyte diseases, in particular sickle cell anaemia. A. Briole, T. Podgorski & B. Abou, Molecular rotors as intracellular probes of red blood cells rigidity, Soft Matter 17, 4525 (2021).